Click Here to return To Results

 

Long-Term Preclinical Magnetic Resonance Imaging Alterations in Sporadic Creutzfeldt-Jakob Disease Ann Neurol 80:629-632, Zanusso, G.,et al, 2016 See this aricle in Pubmed Article Abstract An asymptomatic 74-year-old woman, on follow-up for a carotid body tumor, showed magnetic resonance imaging (MRI) focal restricted diffusion confined to the left temporal and occipital cortices. Thirteen months later, diffusion-weighted images revealed a bilateral cortical ribbon sign involving all lobes. After 1 month, the patient developed gait instability and cognitive decline rapidly evolving to severe dementia and death within 3 months. Prion protein gene sequence, molecular, and neuropathological studies confirmed the diagnosis of sporadic Creutzfeldt-Jakob disease (sCJD) MM1 subtype. Here we show the kinetics of MRI changes and prion spreading in preclinical sCJD MM1.

Related Tags

(click to filter results - removes previous filter) cerebral cortex cerebrovascular accident,misdiagnosis dementia dementia,rapidly progressive gait disorder gyrus,abnormal intellectual deterioration Jakob-Creutzfeldt disease Jakob-Creutzfeldt disease,unilateral misdiagnosis MRI,abnormal MRI,diffusion weighted MRI,serial neuropathology preclinical prion disease symmetric brain lesions

Click Here to return To Results